Long-Term Full-Thickness Skin Organ Culture (Skin Re-innervation)


Monasterium Laboratory has access to the human skin re-innervation model developed by the Misery Lab, University of Brest, where full-thickness skin is co-cultured with and re-innervatived by primary rat dorsal root ganglion neurons. Moreover, we has access to a fully humanized skin re-innervation assay that is currently under development in the Department of Dermatology, University of Münster.


With these models, the vitality of skin samples cultured ex vivo in serum-free medium can be substantially prolonged and test agents are added to the medium (mimicking systemic delivery) or directly onto the epidermis at the air-liquid interphase (testing topical agent application).




Lebonvalet et al. 2014; Chéret et al, 2014. 

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