All Peer-Reviewed Publications

Imanishi H, Ansell DM, Chéret J, Harries M, Bertolini M, Sepp N, Bíró T, Poblet E, Jimenez F, Hardman J, Panicker SP, Ward CMPaus R. Epithelial-mesenchymal stem cell transition in a human organ: lessons from lichen planopilaris. J Invest Dermatol. 2017 In press


Tafazzoli A, Forstner AJ, Broadley D, Hofmann A, Redler S, Petukhova L, Giehl KA, Kruse R, Blaumeiser B, Böhm M, Bertolini M, Rossi A, Garcia Bartels N, Lutz G, Wolff H, Blume-Peytavi U, Soreq H, Christiano AM, Botchkareva NV, Nöthen MM, Betz RC. Genome-wide microRNA analysis implicates miR-30b/d in the etiology of alopecia areata. J Invest Dermatol. 2017. In press


Sardella C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F. Delayed hair follicle morphogenesis and hair follicle dystrophy in a lipoatrophy mouse model of PPARg total deletion. J Invest Dermatol. 2017. In press


Krieger K, Millar SE, Mikuda N, Krahn I, Kloepper JE, Bertolini M, Scheidereit C, Paus R, Schmidt-Ullrich R. NF-κB participates in mouse hair cycle control and plays distinct roles in the various pelage hair follicle types. J Invest Dermatol. 2017. In press


Jadkauskaite L, Coulombe PA, Schäfer M, Dinkova-Kostova AT, Paus R, Haslam IS. Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond? Bioessays. 2017 Aug;39(8).


Lehmann J, Seebode C, Emmert S. Forschung zu Genodermatosen durch neue Genom-Editing-Methoden. J Dtsch Dermatol Ges. 2017 Aug;15(8):783-790.


Dobreva A, Paus R, Cogan NG. Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling. Math Med Biol. 2017.


Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. Regulatory T cells in skin facilitate epithelial stem cell differentiation. Cell. 2017 Jun 1;169(6):1119-1129.e11.


Lehmann J, Seebode C, Smolorz S, Schubert S, Emmert S. XPF knockout via CRISPR/Cas9 reveals that ERCC1 is retained in the cytoplasm without its heterodimer partner XPF. Cell Mol Life Sci. 2017 Jun;74(11):2081-2094.


Stojadinovic O, Wikramanayake TC, Villasante Fricke AC, Yin NC, Liang L, Hinde E, Escandon J, Tomic-Canic M, Ansell DM, Paus R, Jimenez JJ. Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1β-mediated signaling. Heliyon. 2017 May 30;3(5):e00309.


Bertolini M, Rossi A, Paus R. Cover Image: Are melanocyte-associated peptides the elusive autoantigens in alopecia areata?  Br J Dermatol. 2017. 


Xie G, Ao X, Lin T, Zhou G, Wang M, Wang H, Chen Y, Li X, Xu B, He W, Han H, Ramot Y, Paus R, Yue Z. E-cadherin-mediated cell contact controls the epidermal damage response in radiation dermatitis. J Invest Dermatol. 2017.


Purba TS, Brunken L, Peake M, Shahmalak A, Chaves A, Poblet E, Paus RCharacterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix. Eur J Cell Biol. 2017. 


Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nöthen MM. Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. Nat Commun. 2017.


Sebastian A, Volk SW, Halai P, Colthurst J, Paus R, Bayat A. Enhanced neurogenic biomarker expression and reinnervation in human acute skin wounds treated by electrical stimulation. J Invest Dermatol. 2017.


Haslam IS, Jadkauskaite L, Szabó IL, Staege S, Hesebeck-Brinckmann J, Jenkins G, Bhogal RK, Lim FL, Farjo N, Farjo B, Bíró T, Schäfer M, Paus R. Oxidative damage control in a human (nini-) organ: Nrf2 activation protects against oxidative stress-induced hair growth inhibition. J Invest Dermatol. 2017.


Chew EG, Ho BS, Ramasamy S, Dawson T, Tennakoon C, Liu X, Leong WM, Yang SY, Lim SY, Jaffar H, Hillmer AM, Bigliardi-Qi M, Bigliardi PL. Comparative transcriptome profiling provides new insights into mechanisms of androgenetic alopecia progression. Br J Dermatol. 2017 Jan;176(1):265-269. 


Tsai T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmüller J, Ständer S, Luger T, Paus RCheret J, Hatt H. Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. Exp Dermatol. 2017.


Fleger-Weckmann A, Üstün Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis. Matrix Biol. 2016.


Jumper N, Hodgkinson T, Paus R, Bayat A. A Role for neuregulin-1 in promoting keloid Fibroblast Migration via ErbB2-mediated signaling. Acta Derm Venereol. 2016.


O'Neill CA, Monteleone G, McLaughlin JT, Paus R. The gut-skin axis in health and disease: A paradigm with therapeutic implications. Bioessays. 2016.


Bagabir RA, Syed F, Shenjere P, Paus R, Bayat A. Identification of a potential molecular diagnostic biomarker in keloid disease: Syndecan-1 (CD138) is overexpressed in keloid scar tissue. J Invest Dermatol. 2016.


Oelert T, Gilhar A, Paus R. T-cell "induced-self" MHC class I/peptide complexes may enable "de novo" tolerance induction to neo-antigens occurring outside of the thymus: Lessons from the hair follicle. Exp Dermatol. 2016.


Vidali S, Chéret J, Giesen M, Haeger S, Alam M, Watson RE, Langton AK, Klinger M, Knuever J, Funk W, Kofler B, Paus R. Thyroid hormones enhance mitochondrial function in human epidermis. J Invest Dermatol. 2016.


Purba TS, Brunken L, Hawkshaw NJ, Peake M, Hardman J, Paus R. A primer for studying cell cycle dynamics of the human hair follicle. Exp Dermatol. 2016.


Schubert S, Rieper P, Ohlenbusch A, Seebode C, Lehmann J, Gratchev A, Emmert S. A unique chromosomal in-frame deletion identified among seven XP-C patients. Photodermatol Photoimmunol Photomed. 2016 Sep;32(5-6):276-283.


Bertolini M, Pretzlaff M, Sulk M, Bähr M, Gherardini J, Uchida Y, Reibelt M, Kinori M, Rossi A, Bíró T, Paus R. Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse. Br J Dermatol. 2016 Sep;175(3):531-41.


Oláh A, Gherardini J, Bertolini MChéret J, Ponce L, Kloepper J, Bíró T, Soeberdt M, Abels C, Paus R. The thyroid hormone analogue KB2115 (Eprotirome) prolongs human hair growth (anagen) ex vivo. J Invest Dermatol. 2016.


Chew EG, Tan JH, Bahta AW, Ho BS, Liu X, Lim TC, Sia YY, Bigliardi PL, Heilmann S, Wan AC, Nöthen MM, Philpott MP, Hillmer AM. Differential expression between human dermal papilla cells from balding and non-balding scalps reveals new candidate genes for androgenetic alopecia. J Invest Dermatol. 2016 Aug;136(8):1559-67.


Rump A, Benet-Pages A, Schubert S, Kuhlmann JD, Janavičius R, Macháčková E, Foretová L, Kleibl Z, Lhota F, Zemankova P, Betcheva-Krajcir E, Mackenroth L, Hackmann K, Lehmann J, Nissen A, DiDonato N, Opitz R, Thiele H, Kast K, Wimberger P, Holinski-Feder E, Emmert S, Schröck E, Klink B. Identification and functional testing of ERCC2 mutations in a multi-national cohort of patients with familial breast- and ovarian cancer. PLoS Genet. 2016 Aug 9;12(8):e1006248.


Jumper N, Hodgkinson T, Arscott G, Har-Shai Y, Paus R, Bayat A. The aldo-keto reductase AKR1B10 is up-regulated in keloid epidermis, implicating retinoic acid pathway dysregulation in the pathogenesis of keloid disease. J Invest Dermatol. 2016.


Gilhar A, Schrum AG, Etzioni A, Waldmann H, Paus R. Alopecia areata: animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies. Autoimmun Rev. 2016.


Dahlhoff M, Camera E, Schäfer M, Emrich D, Riethmacher D, Foster A, Paus R, Schneider MR. Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice. Development. 2016.


Garcin CL, Ansell DM, Headon DJ, Paus R, Hardman MJ. Hair follicle bulge stem cells appear dispensable for the acute Pphase of wound re-epithelialization. Stem Cells. 2016.


Tomann P, Paus R, Millar SE, Scheidereit C, Schmidt-Ullrich R. Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth. Development. 2016.


Heilmann-Heimbach S, Hochfeld LM, Paus R, Nöthen MM. Hunting the genes in male-pattern alopecia: how important are they, how close are we and what will they tell us? Exp Dermatol. 2016.


Brauns B, Schubert S, Lehmann J, Laspe P, Körner A, Brockmann K, Schön MP, Emmert S. Photosensitive form of trichothiodystrophy associated with a novel mutation in the XPD gene. Photodermatol Photoimmunol Photomed. 2016 Mar;32(2):110-2.


Liao C, Xie G, Zhu L, Chen X, Li X, Lu H, Xu B, Ramot Y, Paus R, Yue Z. p53 is a direct transcriptional repressor of keratin 17: lessons from a rat model of radiation dermatitis. J Invest Dermatol. 2016.


Poblet E, Jiménez-Acosta F, Hardman JA, Escario E, Paus R. Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit? Exp Dermatol. 2016.


Oh JW, Kloepper J, Langan EA, Kim Y, Yeo J, Kim MJ, Hsi TC, Rose C, Yoon GS, Lee SJ, Seykora J, Kim JC, Sung YK, Kim M, Paus R, Plikus MV. A guide to studying human hair follicle cycling in vivo. J Invest Dermatol. 2016.


Langan EA, Philpott MP, Kloepper JE, Paus R. Human hair follicle organ culture: theory, application and perspectives. Exp Dermatol. 2015 Dec


Ramot Y, Marzani B, Pinto D, Kloepper JE, Paus R. N(1)-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles. Arch Dermatol Res. 2015.


Morgner J, Ghatak S, Jakobi T, Dieterich C, Aumailley M, Wickström SA. Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. Nat Commun. 2015 6:8198.


Dobreva A, Paus R, Cogan NG. Mathematical model for alopecia areata. J Theor Biol. 2015.


Warshauer E, Samuelov L, Sarig O, Vodo D, Bindereif A, Kanaan M, Gat U, Fuchs-Telem D, Shomron N, Farberov L, Pasmanik-Chor M, Nardini G, Winkler E, Meilik B, Petit I, Aberdam D, Paus R, Sprecher E, Nousbeck J. RBM28, a protein deficient in ANE syndrome, regulates hair follicle growth via miR-203 and p63. Exp Dermatol. 2015.


Hawkshaw NJ, Haslam IS, Ansell DM, Shamalak A, Paus R. Re-evaluating cyclosporine as a hair growth-promoting agent in human scalp hair follicles. J Invest Dermatol. 2015.


Di Grazia A, Cappiello F, Imanishi A, Mastrofrancesco A, Picardo M, Paus R, Mangoni ML. The frog skin-derived antimicrobial peptide esculentin-1a(1-21)NH2 promotes the migration of human HaCaT keratinocytes in an EGF receptor-dependent manner: a novel promoter of human skin wound healing? PLoS One. 2015.


Purba TS, Haslam IS, Shahmalak A, Bhogal RK, Paus R. Mapping the expression of epithelial hair follicle stem cell-related transcription factors LHX2 and SOX9 in the human hair follicle. Exp Dermatol. 2015.


Samuelov L, Sprecher E, Paus R. The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle. Cell Tissue Res. 2015.


Ramot Y, Mastrofrancesco A, Camera E, Desreumaux P, Paus R, Picardo M. The role of PPARγ-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology. Exp Dermatol. 2015.


Hardman JA, Haslam IS, Farjo N, Farjo B, Paus R. Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle. PLoS One. 2015. 

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