ML Team Member Publications

Imanishi H, Ansell DM, Chéret J, Harries M, Bertolini M, Sepp N, Bíró T, Poblet E, Jimenez F, Hardman J, Panicker SP, Ward CM, Paus R. Epithelial-mesenchymal stem cell transition in a human organ: lessons from lichen planopilaris. J Invest Dermatol. 2017 Oct 26 [Epub ahead of print]

 

 

Tafazzoli A, Forstner AJ, Broadley D, Hofmann A, Redler S, Petukhova L, Giehl KA, Kruse R, Blaumeiser B, Böhm M, Bertolini M, Rossi A, Garcia Bartels N, Lutz G, Wolff H, Blume-Peytavi U, Soreq H, Christiano AM, Botchkareva NV, Nöthen MM, Betz RC. Genome-wide microRNA analysis implicates miR-30b/d in the etiology of alopecia areata. J Invest Dermatol. 2017 Oct 25. [Epub ahead of print]

 

 

Ji J, Ho BS, Qian G, Xie XM, Bigliardi PL, Bigliardi-Qi M. Aging in hair follicle stem cells and niche microenvironment. J Dermatol. 2017 Oct;44(10):1097-1104.

 

 

Sardella C, Winkler C, Quignodon L, Hardman JA, Toffoli B, Giordano Attianese GMP, Hundt JE, Michalik L, Vinson CR, Paus R, Desvergne B, Gilardi F. Delayed hair follicle morphogenesis and hair follicle dystrophy in a lipoatrophy mouse model of PPARg total deletion. J Invest Dermatol. 2017 Sep 27. [Epub ahead of print]

 

 

Krieger K, Millar SE, Mikuda N, Krahn I, Kloepper JE, Bertolini M, Scheidereit C, Paus R, Schmidt-Ullrich R. NF-κB participates in mouse hair cycle control and plays distinct roles in the various pelage hair follicle types. J Invest Dermatol. 2017 Sep 20. [Epub ahead of print]

 

 

Jadkauskaite L, Coulombe PA, Schäfer M, Dinkova-Kostova AT, Paus R, Haslam IS. Oxidative stress management in the hair follicle: Could targeting NRF2 counter age-related hair disorders and beyond? Bioessays. 2017 Aug;39(8).

 

 

Lehmann J, Seebode C, Emmert S. Forschung zu Genodermatosen durch neue Genom-Editing-Methoden. J Dtsch Dermatol Ges. 2017 Aug;15(8):783-790.

 

 

Dobreva A, Paus R, Cogan NG. Analysing the dynamics of a model for alopecia areata as an autoimmune disorder of hair follicle cycling. Math Med Biol. 2017 Aug 7. [Epub ahead of print]

 

 

Ali N, Zirak B, Rodriguez RS, Pauli ML, Truong HA, Lai K, Ahn R, Corbin K, Lowe MM, Scharschmidt TC, Taravati K, Tan MR, Ricardo-Gonzalez RR, Nosbaum A, Bertolini M, Liao W, Nestle FO, Paus R, Cotsarelis G, Abbas AK, Rosenblum MD. Regulatory T cells in skin facilitate epithelial Sstem cell differentiation. Cell. 2017 Jun 1;169(6):1119-1129.e11.

 

 

Lehmann J, Seebode C, Smolorz S, Schubert S, Emmert S. XPF knockout via CRISPR/Cas9 reveals that ERCC1 is retained in the cytoplasm without its heterodimer partner XPF. Cell Mol Life Sci. 2017 Jun;74(11):2081-2094.

 

Stojadinovic O, Wikramanayake TC, Villasante Fricke AC, Yin NC, Liang L, Hinde E, Escandon J, Tomic-Canic M, Ansell DM, Paus R, Jimenez JJ. Wound healing protects against chemotherapy-induced alopecia in young rats via up-regulating interleukin-1β-mediated signaling. Heliyon. 2017 May 30;3(5):e00309.

 

 

Bertolini M, Rossi A, Paus R. Cover Image: Are melanocyte-associated peptides the elusive autoantigens in alopecia areata?  Br J Dermatol. 2017 Apr. [Epub ahead of print]

 

 

Xie G, Ao X, Lin T, Zhou G, Wang M, Wang H, Chen Y, Li X, Xu B, He W, Han H, Ramot Y, Paus R, Yue Z. E-cadherin-mediated cell contact controls the epidermal damage response in radiation dermatitis. J Invest Dermatol. 2017 Apr 26. [Epub ahead of print]

 

 

Purba TS, Brunken L, Peake M, Shahmalak A, Chaves A, Poblet E, Paus RCharacterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle

matrix. Eur J Cell Biol. 2017 Apr 2. [Epub ahead of print]

 

 

Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J, Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL, Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S, Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD, Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG, Becker T, Hinds DA, Nöthen MM. Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness. Nat Commun. 2017 Mar 8

 

 

Sebastian A, Volk SW, Halai P, Colthurst J, Paus R, Bayat A. Enhanced neurogenic biomarker expression and reinnervation in human acute skin wounds treated by electrical stimulation. J Invest Dermatol. 2017 Mar

 

 

Haslam IS, Jadkauskaite L, Szabó IL, Staege S, Hesebeck-Brinckmann J, Jenkins G, Bhogal RK, Lim FL, Farjo N, Farjo B, Bíró T, Schäfer M, Paus R. Oxidative damage control in a human (nini-) organ: Nrf2 activation protects against oxidative stress-induced hair growth inhibition. J Invest Dermatol. 2017 Feb

 

 

Chew EG, Ho BS, Ramasamy S, Dawson T, Tennakoon C, Liu X, Leong WM, Yang SY, Lim SY, Jaffar H, Hillmer AM, Bigliardi-Qi M, Bigliardi PL. Comparative transcriptome profiling provides new insights into mechanisms of androgenetic alopecia progression. Br J Dermatol. 2017 Jan;176(1):265-269. 

 

 

Tsai T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N, Wojcik S, Gisselmann G, Altmüller J, Ständer S, Luger T, Paus RCheret J, Hatt H. Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal proliferation and differentiation. Exp Dermatol. 2017 Jan

 

Fleger-Weckmann A, Üstün Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. Deletion of the epidermis derived laminin γ1 chain leads to defects in the regulation of late hair morphogenesis. Matrix Biol. 2016 Dec

 

 

Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, Werner S, Sorokin L. Laminin α5 in the keratinocyte basement membrane is required for epidermal-dermal intercommunication. Matrix Biol. 2016 Dec

 

 

Jumper N, Hodgkinson T, Paus R, Bayat A. A Role for neuregulin-1 in promoting keloid Fibroblast Migration via ErbB2-mediated signaling. Acta Derm Venereol. 2016 Nov 24 [Epub ahead of print].

 

 

O'Neill CA, Monteleone G, McLaughlin JT, Paus R. The gut-skin axis in health and disease: A paradigm with therapeutic implications. Bioessays. 2016 Nov

 

 

Bagabir RA, Syed F, Shenjere P, Paus R, Bayat A. Identification of a potential molecular diagnostic biomarker in keloid disease: Syndecan-1 (CD138) is

overexpressed in keloid scar tissue. J Invest Dermatol. 2016 Nov

 

 

Ghatak S, Niland S, Schulz JN, Wang F, Eble JA, Leitges M, Mauch C, Krieg T, Zigrino P, Eckes B. Role of integrins α1β1 and α2β1 in wound and tumor angiogenesis in mice. Am J Pathol. 2016 Nov;186(11):3011-3027.

 

 

Oelert T, Gilhar A, Paus R. T-cell "induced-self" MHC class I/peptide complexes may enable "de novo" tolerance induction to neo-antigens occurring outside of the thymus: Lessons from the hair follicle. Exp Dermatol. 2016 Oct 7 [Epub ahead of print]

 

 

Vidali S, Chéret J, Giesen M, Haeger S, Alam M, Watson RE, Langton AK, Klinger M, Knuever J, Funk W, Kofler B, Paus R. Thyroid hormones enhance mitochondrial function in human epidermis. J Invest Dermatol. 2016 Oct

 

 

Purba TS, Brunken L, Hawkshaw NJ, Peake M, Hardman J, Paus R. A primer for studying cell cycle dynamics of the human hair follicle. Exp Dermatol. 2016 Sep

 

 

Schubert S, Rieper P, Ohlenbusch A, Seebode C, Lehmann J, Gratchev A, Emmert S. A unique chromosomal in-frame deletion identified among seven XP-C patients. Photodermatol Photoimmunol Photomed. 2016 Sep;32(5-6):276-283.

 

 

Bertolini M, Pretzlaff M, Sulk M, Bähr M, Gherardini J, Uchida Y, Reibelt M, Kinori M, Rossi A, Bíró T, Paus R. Vasoactive intestinal peptide, whose receptor-mediated signalling may be defective in alopecia areata, provides protection from hair follicle immune privilege collapse. Br J Dermatol. 2016 Sep;175(3):531-41.

 

 

Le HQ, Ghatak S, Yeung CY, Tellkamp F, Günschmann C, Dieterich C, Yeroslaviz A, Habermann B, Pombo A, Niessen CM, Wickström SA. Mechanical regulation of transcription controls Polycomb-mediated gene silencing during lineage commitment. Nat Cell Biol. 2016 Aug;18(8):864-75.

 

 

Oláh A, Gherardini JBertolini MChéret J, Ponce L, Kloepper J, Bíró T, Soeberdt M, Abels C, Paus R. The thyroid hormone analogue KB2115 (Eprotirome) prolongs human hair growth (anagen) ex vivo. J Invest Dermatol. 2016 Aug

 

 

Chew EG, Tan JH, Bahta AW, Ho BS, Liu X, Lim TC, Sia YY, Bigliardi PL, Heilmann S, Wan AC, Nöthen MM, Philpott MP, Hillmer AM. Differential expression between human dermal papilla cells from balding and non-balding scalps reveals new candidate genes for androgenetic alopecia. J Invest Dermatol. 2016 Aug;136(8):1559-67.

 

 

Rump A, Benet-Pages A, Schubert S, Kuhlmann JD, Janavičius R, Macháčková E, Foretová L, Kleibl Z, Lhota F, Zemankova P, Betcheva-Krajcir E, Mackenroth L, Hackmann K, Lehmann J, Nissen A, DiDonato N, Opitz R, Thiele H, Kast K, Wimberger P, Holinski-Feder E, Emmert S, Schröck E, Klink B. Identification and functional testing of ERCC2 mutations in a multi-national cohort of patients with familial breast- and ovarian cancer. PLoS Genet. 2016 Aug 9;12(8):e1006248.

 

 

Jumper N, Hodgkinson T, Arscott G, Har-Shai Y, Paus R, Bayat A. The aldo-keto reductase AKR1B10 is up-regulated in keloid epidermis, implicating retinoic acid pathway dysregulation in the pathogenesis of keloid disease. J Invest Dermatol. 2016 Jul

 

 

Gilhar A, Schrum AG, Etzioni A, Waldmann H, Paus R. Alopecia areata: animal models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies. Autoimmun Rev. 2016 Jul

 

 

Dahlhoff M, Camera E, Schäfer M, Emrich D, Riethmacher D, Foster A, Paus R, Schneider MR. Sebaceous lipids are essential for water repulsion, protection against UVB-induced apoptosis and ocular integrity in mice. Development. 2016 May 15

 

 

Garcin CL, Ansell DM, Headon DJ, Paus R, Hardman MJ. Hair follicle bulge stem cells appear dispensable for the acute Pphase of wound re-epithelialization. Stem Cells. 2016 May

 

 

Tomann P, Paus R, Millar SE, Scheidereit C, Schmidt-Ullrich R. Lhx2 is a direct NF-κB target gene that promotes primary hair follicle placode down-growth. Development. 2016 May 1

 

 

Heilmann-Heimbach S, Hochfeld LM, Paus R, Nöthen MM. Hunting the genes in male-pattern alopecia: how important are they, how close are we and what will they tell us? Exp Dermatol. 2016 Apr

 

 

Brauns B, Schubert S, Lehmann J, Laspe P, Körner A, Brockmann K, Schön MP, Emmert S. Photosensitive form of trichothiodystrophy associated with a novel mutation in the XPD gene. Photodermatol Photoimmunol Photomed. 2016 Mar;32(2):110-2.

 

 

Liao C, Xie G, Zhu L, Chen X, Li X, Lu H, Xu B, Ramot Y, Paus R, Yue Z. p53 is a direct transcriptional repressor of keratin 17: lessons from a rat model of radiation dermatitis. J Invest Dermatol. 2016 Mar 

 

 

Poblet E, Jiménez-Acosta F, Hardman JA, Escario E, Paus R. Is the eccrine gland an integral, functionally important component of the human scalp pilosebaceous unit? Exp Dermatol. 2016 Feb 

 

 

Oh JW, Kloepper J, Langan EA, Kim Y, Yeo J, Kim MJ, Hsi TC, Rose C, Yoon GS, Lee SJ, Seykora J, Kim JC, Sung YK, Kim M, Paus R, Plikus MV. A guide to studying human hair follicle cycling in vivo. J Invest Dermatol. 2016 Jan

 

 

Bertolini M, Uchida Y, Paus R. Toward the clonotype analysis of alopecia areata-specific, intralesional human CD8+ T lymphocytes. J Investig Dermatol Symp Proc. 2015 Nov

 

 

Langan EA, Philpott MP, Kloepper JE, Paus R. Human hair follicle organ culture: theory, application and perspectives. Exp Dermatol. 2015 Dec

 

 

Ramot Y, Marzani B, Pinto D, Kloepper JE, Paus R. N(1)-methylspermidine, a stable spermidine analog, prolongs anagen and regulates epithelial stem cell functions in human hair follicles. Arch Dermatol Res. 2015 Nov

 

 

Morgner J, Ghatak S, Jakobi T, Dieterich C, Aumailley M, Wickström SA. Integrin-linked kinase regulates the niche of quiescent epidermal stem cells. Nat Commun. 2015 Sep 8;6:8198.

 

 

Dobreva A, Paus R, Cogan NG. Mathematical model for alopecia areata. J Theor Biol. 2015 Sep 7

 

 

Warshauer E, Samuelov L, Sarig O, Vodo D, Bindereif A, Kanaan M, Gat U, Fuchs-Telem D, Shomron N, Farberov L, Pasmanik-Chor M, Nardini G, Winkler E, Meilik B, Petit I, Aberdam D, Paus R, Sprecher E, Nousbeck J. RBM28, a protein deficient in ANE syndrome, regulates hair follicle growth via miR-203 and p63. Exp Dermatol. 2015 Aug

 

 

Hawkshaw NJ, Haslam IS, Ansell DM, Shamalak A, Paus R. Re-evaluating cyclosporine a as a hair growth-promoting agent in human scalp hair follicles. J Invest Dermatol. 2015 Aug

 

 

Di Grazia A, Cappiello F, Imanishi A, Mastrofrancesco A, Picardo M, Paus R, Mangoni ML. The frog skin-derived antimicrobial peptide esculentin-1a(1-21)NH2 promotes the migration of human HaCaT keratinocytes in an EGF receptor-dependent manner: a novel promoter of human skin wound healing? PLoS One. 2015 Jun 12

 

 

Purba TS, Haslam IS, Shahmalak A, Bhogal RK, Paus R. Mapping the expression of epithelial hair follicle stem cell-related transcription factors LHX2 and SOX9 in the human hair follicle. Exp Dermatol. 2015 Jun

 

 

Samuelov L, Sprecher E, Paus R. The role of P-cadherin in skin biology and skin pathology: lessons from the hair follicle. Cell Tissue Res. 2015 Jun

 

 

Ramot Y, Mastrofrancesco A, Camera E, Desreumaux P, Paus R, Picardo M. The role of PPARγ-mediated signalling in skin biology and pathology: new targets and opportunities for clinical dermatology. Exp Dermatol. 2015 Apr

 

 

Hardman JA, Haslam IS, Farjo N, Farjo B, Paus R. Thyroxine differentially modulates the peripheral clock: lessons from the human hair follicle. PLoS One. 2015 Mar 30

 

 

 

 

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