ML Team Member Publications

Cover Image: Are melanocyte-associated peptides the elusive autoantigens in alopecia areata? Bertolini M, Rossi A, Paus R. Br J Dermatol. 2017 Apr. [Epub ahead of print]



Xie G, Ao X, Lin T, Zhou G, Wang M, Wang H, Chen Y, Li X, Xu B, He W, Han H,

Ramot Y, Paus R, Yue Z. E-cadherin-mediated Cell Contact Controls the Epidermal

Damage Response in Radiation Dermatitis. J Invest Dermatol. 2017 Apr 26.

[Epub ahead of print]



Purba TS, Brunken L, Peake M, Shahmalak A, Chaves A, Poblet E, Paus R.

Characterisation of cell cycle arrest and terminal differentiation in a maximally

proliferative human epithelial tissue: Lessons from the human hair follicle

matrix. Eur J Cell Biol. 2017 Apr 2. [Epub ahead of print]



Heilmann-Heimbach S, Herold C, Hochfeld LM, Hillmer AM, Nyholt DR, Hecker J,

Javed A, Chew EG, Pechlivanis S, Drichel D, Heng XT, Del Rosario RC, Fier HL,

Paus R, Rueedi R, Galesloot TE, Moebus S, Anhalt T, Prabhakar S, Li R, Kanoni S,

Papanikolaou G, Kutalik Z, Deloukas P, Philpott MP, Waeber G, Spector TD,

Vollenweider P, Kiemeney LA, Dedoussis G, Richards JB, Nothnagel M, Martin NG,

Becker T, Hinds DA, Nöthen MM. Meta-analysis identifies novel risk loci and

yields systematic insights into the biology of male-pattern baldness. Nat Commun.

2017 Mar 8



Sebastian A, Volk SW, Halai P, Colthurst J, Paus R, Bayat A. Enhanced

Neurogenic Biomarker Expression and Reinnervation in Human Acute Skin Wounds

Treated by Electrical Stimulation. J Invest Dermatol. 2017 Mar



Tsai T, Veitinger S, Peek I, Busse D, Eckardt J, Vladimirova D, Jovancevic N,

Wojcik S, Gisselmann G, Altmüller J, Ständer S, Luger T, Paus R, Cheret J, Hatt

H. Two olfactory receptors-OR2A4/7 and OR51B5-differentially affect epidermal

proliferation and differentiation. Exp Dermatol. 2017 Jan



Jumper N, Hodgkinson T, Paus R, Bayat A. A Role for Neuregulin-1 in Promoting

Keloid Fibroblast Migration via ErbB2-mediated Signaling. Acta Derm Venereol.

2016 Nov 24 [Epub ahead of print].



O'Neill CA, Monteleone G, McLaughlin JT, Paus R. The gut-skin axis in health

and disease: A paradigm with therapeutic implications. Bioessays. 2016




Bagabir RA, Syed F, Shenjere P, Paus R, Bayat A. Identification of a Potential

Molecular Diagnostic Biomarker in Keloid Disease: Syndecan-1 (CD138) Is

Overexpressed in Keloid Scar Tissue. J Invest Dermatol. 2016




Oelert T, Gilhar A, Paus R. T-cell "induced-self" MHC class I/peptide

complexes may enable "de novo" tolerance induction to neo-antigens occurring

outside of the thymus: Lessons from the hair follicle. Exp Dermatol. 2016 Oct 7
[Epub ahead of print]




Haslam IS, Jadkauskaite L, Szabó IL, Staege S, Hesebeck-Brinckmann J, Jenkins

G, Bhogal RK, Lim FL, Farjo N, Farjo B, Bíró T, Schäfer M, Paus R. Oxidative

Damage Control in a Human (Mini-) Organ: Nrf2 Activation Protects against

Oxidative Stress-Induced Hair Growth Inhibition. J Invest Dermatol. 2017




Vidali S, Chéret J, Giesen M, Haeger S, Alam M, Watson RE, Langton AK,

Klinger M, Knuever J, Funk W, Kofler B, Paus R. Thyroid Hormones Enhance

Mitochondrial Function in Human Epidermis. J Invest Dermatol. 2016 Oct



Fleger-Weckmann A, Üstün Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J,

Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R. Deletion of the

epidermis derived laminin γ1 chain leads to defects in the regulation of late

hair morphogenesis. Matrix Biol. 2016 Dec



Wegner J, Loser K, Apsite G, Nischt R, Eckes B, Krieg T, Werner S, Sorokin L.

Laminin α5 in the keratinocyte basement membrane is required for epidermal-dermal

intercommunication. Matrix Biol. 2016 Dec



Purba TS, Brunken L, Hawkshaw NJ, Peake M, Hardman J, Paus R. A primer for

studying cell cycle dynamics of the human hair follicle. Exp Dermatol. 2016




Oláh A, Gherardini J, Bertolini M, Chéret J, Ponce L, Kloepper J, Bíró T, Soeberdt M, Abels C, Paus R. The Thyroid Hormone Analogue KB2115 (Eprotirome)

Prolongs Human Hair Growth (Anagen) Ex Vivo. J Invest Dermatol. 2016




Jumper N, Hodgkinson T, Arscott G, Har-Shai Y, Paus R, Bayat A. The Aldo-Keto

Reductase AKR1B10 Is Up-Regulated in Keloid Epidermis, Implicating Retinoic Acid

Pathway Dysregulation in the Pathogenesis of Keloid Disease. J Invest Dermatol.

2016 Jul



Dahlhoff M, Camera E, Schäfer M, Emrich D, Riethmacher D, Foster A, Paus R,

Schneider MR. Sebaceous lipids are essential for water repulsion, protection

against UVB-induced apoptosis and ocular integrity in mice. Development. 2016 May 15



Gilhar A, Schrum AG, Etzioni A, Waldmann H, Paus R. Alopecia areata: Animal

models illuminate autoimmune pathogenesis and novel immunotherapeutic strategies.

Autoimmun Rev. 2016 Jul



Tomann P, Paus R, Millar SE, Scheidereit C, Schmidt-Ullrich R. Lhx2 is a

direct NF-κB target gene that promotes primary hair follicle placode down-growth.

Development. 2016 May 1



Heilmann-Heimbach S, Hochfeld LM, Paus R, Nöthen MM. Hunting the genes in

male-pattern alopecia: how important are they, how close are we and what will

they tell us? Exp Dermatol. 2016 Apr



Oh JW, Kloepper J, Langan EA, Kim Y, Yeo J, Kim MJ, Hsi TC, Rose C, Yoon GS,

Lee SJ, Seykora J, Kim JC, Sung YK, Kim M, Paus R, Plikus MV. A Guide to Studying

Human Hair Follicle Cycling In Vivo. J Invest Dermatol. 2016 Jan



Garcin CL, Ansell DM, Headon DJ, Paus R, Hardman MJ. Hair Follicle Bulge Stem

Cells Appear Dispensable for the Acute Phase of Wound Re-epithelialization. Stem

Cells. 2016 May



Liao C, Xie G, Zhu L, Chen X, Li X, Lu H, Xu B, Ramot Y, Paus R, Yue Z. p53

Is a Direct Transcriptional Repressor of Keratin 17: Lessons from a Rat Model

of Radiation Dermatitis. J Invest Dermatol. 2016 Mar


Poblet E, Jiménez-Acosta F, Hardman JA, Escario E, Paus R. Is the eccrine

gland an integral, functionally important component of the human scalp

pilosebaceous unit? Exp Dermatol. 2016 Feb


 Bertolini M, Uchida Y, Paus R. Toward the Clonotype Analysis of Alopecia

Areata-Specific, Intralesional Human CD8+ T Lymphocytes. J Investig Dermatol Symp

Proc. 2015 Nov



Langan EA, Philpott MP, Kloepper JE, Paus R. Human hair follicle organ

culture: theory, application and perspectives. Exp Dermatol. 2015




Ramot Y, Marzani B, Pinto D, Kloepper JE, Paus R. N(1)-methylspermidine, a

stable spermidine analog, prolongs anagen and regulates epithelial stem cell

functions in human hair follicles. Arch Dermatol Res. 2015 Nov



Di Grazia A, Cappiello F, Imanishi A, Mastrofrancesco A, Picardo M, Paus R,

Mangoni ML. The Frog Skin-Derived Antimicrobial Peptide Esculentin-1a(1-21)NH2

Promotes the Migration of Human HaCaT Keratinocytes in an EGF Receptor-Dependent

Manner: A Novel Promoter of Human Skin Wound Healing? PLoS One. 2015 Jun




Dobreva A, Paus R, Cogan NG. Mathematical model for alopecia areata. J Theor

Biol. 2015 Sep 7



Warshauer E, Samuelov L, Sarig O, Vodo D, Bindereif A, Kanaan M, Gat U,

Fuchs-Telem D, Shomron N, Farberov L, Pasmanik-Chor M, Nardini G, Winkler E,

Meilik B, Petit I, Aberdam D, Paus R, Sprecher E, Nousbeck J. RBM28, a protein

deficient in ANE syndrome, regulates hair follicle growth via miR-203 and p63.

Exp Dermatol. 2015 Aug



Hawkshaw NJ, Haslam IS, Ansell DM, Shamalak A, Paus R. Re-Evaluating

Cyclosporine A as a Hair Growth-Promoting Agent in Human Scalp Hair Follicles. J

Invest Dermatol. 2015 Aug



Hardman JA, Haslam IS, Farjo N, Farjo B, Paus R. Thyroxine differentially

modulates the peripheral clock: lessons from the human hair follicle. PLoS One.

2015 Mar 30



Purba TS, Haslam IS, Shahmalak A, Bhogal RK, Paus R. Mapping the expression

of epithelial hair follicle stem cell-related transcription factors LHX2 and SOX9

in the human hair follicle. Exp Dermatol. 2015 Jun



Samuelov L, Sprecher E, Paus R. The role of P-cadherin in skin biology and

skin pathology: lessons from the hair follicle. Cell Tissue Res. 2015




Ramot Y, Mastrofrancesco A, Camera E, Desreumaux P, Paus R, Picardo M. The

role of PPARγ-mediated signalling in skin biology and pathology: new targets and

opportunities for clinical dermatology. Exp Dermatol. 2015 Apr


Bertolini M, Uchida Y, Paus R. Toward the Clonotype Analysis of Alopecia

Areata-Specific, Intralesional Human CD8+ T Lymphocytes. J Investig Dermatol Symp Proc. 2015 Nov

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