Humanized Mouse Model: Human Skin Xenotransplants In Vivo


In close collaboration with Prof. Amos Gilhar, Technion Israel Institute, Haifa, Israel, ML has access to unique mouse models which permit one to study human skin xenotransplants onto SCID mice in vivo, in which it is possible to test the effects of test agents on human hair growth &n pigmentation and on numerous other dermatological read-out parameters in vivo.


In addition to the best currently available humanized alopecia areata mouse model, we can utilize the Gilhar Lab’s exceptionally instructive, well-established humanized mouse models for psoriasis, androgenetic alopecia and aging to pre-clinically test new therapeutic strategies at the highest level of preclinical experimentation that is possible before the clinical trial stage .


This xenotransplant model is currently being further developed to also study human chemotherapy-induced alopecia or atopic dermatitis in vivo.


As references see:

Gilhar et al. 2016; Oh et al. 2016; Keren et al. 2016; Gilhar et al. 2011; Shafer et al. 2010; Gilhar et al. 2004.

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