Hair growth

We use ex vivo culture of human hair follicles and human full thickness skin, and the humanized mouse in vivo model to investigate whether compounds/formulations (also via topical application) promote or inhibit hair growth. Specifically, as standardized readout parameters, we evaluate the following by morphology and immunohistology/quantitative (immuno-)histomorphometry (for details on our techniques, please click here):

In addition, using RNAseq, qRT-PCR, and/or in situ hybridization, we can analyse the expression of molecules involved in anagen/catagen conversation, and assess these within specific compartments from skin or hair tissue sections following laser capture microdissection.

Additional readout parameters are available, and customized experiments can be designed to meet the needs of our customers.

Platt et al., 2022, Bertolini et al., 2020, Jimenez et al., 2020, Szabó et al.,2020, Fischer et al., 2020, Hundt et al., 2020, Alam et al., 2020, Laufer etal., 2020, Lisztes et al., 2020, Chéret et al., 2018, Haslam et al., 2018, Alam et al., 2018, Parodi et al, 2018, Hawkshaw et al., 2018, Olah et al., 2016, Langan et al., 2015, Kloepper et al.,2010